The Effect of Turmeric Rhizome Extract Nanoemulsion Preparation (Curcuma Domestica Val.) on the Reduction of C-Reactive Protein (CRP) and Myeloperoxidase (MPO) Levels in Wistar Rats with Diabetes Mellitus

DOI

10.2991/978-94-6463-962-9_16How to use a DOI?

Keywords

Nanoemulsion Turmeric; CRP; MPO

Abstract

This study aims to evaluate the influence of turmeric rhizome extract nanoemulsion Curcuma domestica Val on the reduction of C Reactive Protein CRP and Myeloperoxidase MPO levels in Wistar rats with diabetes mellitus. The results of the study showed that GC MS analysis of turmeric compounds included several bioactive chemicals with health benefits. The major compounds identified were curcumin thirty percent, demethoxycurcumin fifteen point three percent, bisdemethoxycurcumin eight point two percent, turmerone five point seven percent, zingiberene forty one percent, beta turmerone two point eight percent, and volatile compounds thirty three point four percent. The treatment group given a nanoemulsion of turmeric rhizome extract at a dose of two hundred milligrams per kilogram body weight showed the most optimal results, with a significant decrease in CRP and MPO levels, approaching the values of the control group. Histopathological examination of the pancreas indicated that the group receiving a dose of two hundred eighty milligrams per kilogram body weight displayed minimal tissue damage, with less than twenty five percent necrotic cells and fewer than ten inflammatory cells in the pancreatic interstitial space. Both biomarkers confirmed the positive anti inflammatory effect of turmeric extract. The conclusion of this study is that turmeric rhizome extract nanoemulsion is effective in reducing CRP and MPO levels.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Reski Guslina
AU  - Chrismis Novalinda Ginting
AU  - Linda Chiuman
PY  - 2026
DA  - 2026/01/02
TI  - The Effect of Turmeric Rhizome Extract Nanoemulsion Preparation (Curcuma Domestica Val.) on the Reduction of C-Reactive Protein (CRP) and Myeloperoxidase (MPO) Levels in Wistar Rats with Diabetes Mellitus
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 150
EP  - 163
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_16
DO  - 10.2991/978-94-6463-962-9_16
ID  - Guslina2026
ER  -