Effectiveness of Gc-Ms Instrument Analysis of Mint Leaf Extract Nanoemulsion Preparation (Mentha Piperita L) Against Serum Urea Levels And Glomerular Filtration Rate (Lfg) of Alloxan-Induced Hyperglycemic Wistar Rats and Histopathological Features of Kidney

DOI

10.2991/978-94-6463-962-9_17How to use a DOI?

Keywords

Gc - Ms. Mint leaves; Urea; GFR; Kidney

Abstract

This study aims to evaluate the effectiveness of mint leaf extract nanoemulsion (Mentha piperita L) on serum urea levels and glomerular filtration rate (GFR) in alloxan-induced hyperglycemic Wistar rats. The active substance content in mint leaf extract (Mentha piperita L) through Gc Ms Analysis, namely Menthol: 45%, Menthone : 20%, Isomenthone: 10%, Limonene : 5%, Cineole (Eucalyptol) : 3%, Borneol : 2%, Carvone : 1% and Other Compounds : 14% (including fatty acids and other minor compounds). Based on the differences in the average values of urea and creatinine levels, it was concluded that treatment group 3, namely rats that experienced hyperglycemia after being induced by alloxan and given nanoemulsion of mint leaf extract (Mentha piperita L) with a concentration of 5% had the greatest decrease in urea and creatinine levels and was close to the control group and it can also be said that administration of nanoemulsion of mint leaf extract (Mentha piperita L) with concentrations of 3%, 4% and 5% can reduce creatinine levels in rats experiencing hyperglycemia. The histopathological picture of the kidneys showed improvements in the tissue, indicating the potential of mint extract as a therapy for kidney disorders related to hyperglycemia. This study concluded that nanoemulsion of mint leaf extract can be an effective alternative in managing kidney health.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Cicka Nabilla
AU  - Chrismis Novalinda Ginting
AU  - Linda Chiuman
PY  - 2026
DA  - 2026/01/02
TI  - Effectiveness of Gc-Ms Instrument Analysis of Mint Leaf Extract Nanoemulsion Preparation (Mentha Piperita L) Against Serum Urea Levels And Glomerular Filtration Rate (Lfg) of Alloxan-Induced Hyperglycemic Wistar Rats and Histopathological Features of Kidney
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 164
EP  - 174
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_17
DO  - 10.2991/978-94-6463-962-9_17
ID  - Nabilla2026
ER  -