Evaluation of Coelomic Fluid from Earthworms (Eudrilus eugeniae) for Improving Skin Hydration and Collagen Histology in UVB-Exposed Wistar Rats

DOI

10.2991/978-94-6463-962-9_18How to use a DOI?

Keywords

Coelomic fluid; Histophatology; collagen; Skin hydration

Abstract

Maintaining the natural moisture balance of the skin is referred to as skin hydration. This is achieved by supplying the skin with adequate moisture. Prolonged exposure to ultraviolet B radiation causes the skin to produce reactive oxygen species. Excessive reactive oxygen species triggers the activation of protein kinase pathways, which in turn stimulates neutrophils to release more matrix metalloproteinase enzymes that degrade collagen. The aim of this study was to evaluate the effectiveness of earthworm coelomic fluid in improving skin hydration and collagen histology in ultraviolet B-exposed Wistar rats. This research was an experimental study using a pre- and post-test control group design. The dependent variables were water content, oil content, and collagen histology of the ultraviolet B-exposed Wistar rats’ skin. The independent variable was coelomic fluid derived from the earthworm Eudrilus eugeniae. The Kruskal-Wallis test results showed that the p-value for water content was 0.015, for oil content was 0.008, and for collagen histology was 0.050. Based on the research data, it was concluded that coelomic fluid is capable of increasing skin water content, oil content, and collagen levels by day twenty-one.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Angel Jonathane Halim
AU  - Chrismis Novalinda Ginting
AU  - Linda Chiuman
AU  - Setia Budi Tarigan
AU  - Robby Gunawan Sebayang
PY  - 2026
DA  - 2026/01/02
TI  - Evaluation of Coelomic Fluid from Earthworms (Eudrilus eugeniae) for Improving Skin Hydration and Collagen Histology in UVB-Exposed Wistar Rats
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 175
EP  - 195
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_18
DO  - 10.2991/978-94-6463-962-9_18
ID  - Halim2026
ER  -