Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)

<Previous Article In Volume
Next Article In Volume>

Assessing the Effectiveness of Beetroot (Beta vulgaris) Extract as a Nephroprotective and Anti-Hypercholesterolemic Agent in D-Galactose Induced Wistar Rats

Authors
Jesslyn Jesslyn1, Linda Chiuman1, *, Chrismis Novalinda Ginting1
1Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, Medan, Indonesia
*Corresponding author. Email: lindachiuman@unprimdn.ac.id
Corresponding Author
Linda Chiuman
Available Online 2 January 2026.
DOI
10.2991/978-94-6463-962-9_8How to use a DOI?
Keywords
Beetroot Extract; Nephroprotector; Anti-hypercholesterol
Abstract

Previous studies have shown that antioxidants in beetroot (Beta vulgaris) extract may aid in nephron protection and exhibit anti-hypercholesterolemic effects by reducing reactive oxygen species (ROS). This study aimed to evaluate the effectiveness of beetroot extract as a nephroprotective and anti-hypercholesterolemic agent in D-galactose-induced Wistar rats, to support the potential use of beetroot as a natural health supplement. This research employed an experimental laboratory and histopathological approach using a true experimental design with a post-test-only control group. The research sample consisted of 35 male Wistar rats aged six to eight weeks, obtained from the Pharmacy Laboratory, which met the inclusion and exclusion criteria. The samples were induced with D-galactose and subsequently administered beetroot extract and vitamin C as interventions. The results demonstrated that beetroot extract exhibited significant nephroprotective effects with p-values of 0.000, 0.001, 0.001, 0.006, 0.000, and 0.000, and significant anti-hypercholesterolemic effects with a p-value of 0.000. Beetroot extract at a dose of 500 mg/kg body weight showed more significant nephroprotective and anti-hypercholesterolemic effects compared to 250 mg/kg body weight, indicating its potential as a natural therapeutic supplement.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

<Previous Article In Volume
Next Article In Volume>
Volume Title
Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
Series
Advances in Health Sciences Research
Publication Date
2 January 2026
ISBN
978-94-6463-962-9
ISSN
2468-5739
DOI
10.2991/978-94-6463-962-9_8How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Jesslyn Jesslyn
AU  - Linda Chiuman
AU  - Chrismis Novalinda Ginting
PY  - 2026
DA  - 2026/01/02
TI  - Assessing the Effectiveness of Beetroot (Beta vulgaris) Extract as a Nephroprotective and Anti-Hypercholesterolemic Agent in D-Galactose Induced Wistar Rats
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 69
EP  - 76
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_8
DO  - 10.2991/978-94-6463-962-9_8
ID  - Jesslyn2026
ER  -