The Effect of Earthworm Coelomic Fluid on Hyperpigmentation in Wistar Rats Exposed to UVB Rays

Michelle Tandiono; Chrismis Novalinda Ginting; Linda Chiuman; Ade Arhamni; Janice Janice

doi:10.2991/978-94-6463-962-9_20

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The Effect of Earthworm Coelomic Fluid on Hyperpigmentation in Wistar Rats Exposed to UVB Rays

Authors

Michelle Tandiono¹, Chrismis Novalinda Ginting¹^{, *}, Linda Chiuman¹, Ade Arhamni¹, Janice Janice¹

¹Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia

^*Corresponding author. Email: chrismis@unprimdn.ac.id

Corresponding Author

Chrismis Novalinda Ginting

Available Online 2 January 2026.

DOI: 10.2991/978-94-6463-962-9_20 How to use a DOI?
Keywords: Eudrilus euginiae; Coelomic fluid; Hyperpigmentation; UVB radiation; Melanin
Abstract: Hyperpigmentation can be treated using topical, systemic, or procedural approaches. Eudrilus eugeniae earthworms, abundant in Indonesia, have potential skin benefits, including blemish reduction and skin tightening. This study evaluated the effect of E. eugeniae coelomic fluid on hyperpigmentation in UVB-exposed Wistar rats. Thirty rats were randomized into control (distilled water), standard (Emina Aloe Vera Face Mist), and treatment (coelomic fluid) groups for 21 days, followed by UVB exposure (311 nm). Histological analysis assessed melanin content and epidermal thickness. Melanin levels were comparable across groups (<40). A significant difference in epidermal thickness was observed only between the control and standard groups (p = 0.007), with no significant difference involving the coelomic fluid group (p > 0.05). The coelomic fluid did not significantly affect pigmentation or epidermal thickness, suggesting higher concentrations may be needed.
Copyright: © 2025 The Author(s)
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
Series: Advances in Health Sciences Research
Publication Date: 2 January 2026
ISBN: 978-94-6463-962-9
ISSN: 2468-5739
DOI: 10.2991/978-94-6463-962-9_20 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Michelle Tandiono
AU  - Chrismis Novalinda Ginting
AU  - Linda Chiuman
AU  - Ade Arhamni
AU  - Janice Janice
PY  - 2026
DA  - 2026/01/02
TI  - The Effect of Earthworm Coelomic Fluid on Hyperpigmentation in Wistar Rats Exposed to UVB Rays
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 205
EP  - 211
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_20
DO  - 10.2991/978-94-6463-962-9_20
ID  - Tandiono2026
ER  -

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