The Effect of Turmeric (Curcuma longa) Extract Administration on Malondialdehyde (MDA) Levels and Superoxide Dismutase (SOD) Activity in Wistar Rats (Rattus norvegicus) Induced by Excessive Physical Activity

DOI

10.2991/978-94-6463-962-9_10How to use a DOI?

Keywords

Turmeric Extract; Oxidative Stress; Malondialdehyde; Superoxide Dismutase; Physical Activity

Abstract

Excessive physical activity can increase the production of free radicals, which may cause oxidative stress if the body’s antioxidant system cannot handle it. This study aimed to find out whether turmeric extract can help reduce malondialdehyde (MDA) levels and increase superoxide dismutase (SOD) activity in rats that were given physical stress. A total of 30 Wistar rats were divided into five groups, including two control groups and three treatment groups that received turmeric extract at doses of 100, 200, and 400 mg/kg body weight for 14 days. All groups, except the negative control, were made to swim for around 40 minutes daily. MDA levels were measured using the TBARS method, and SOD activity was measured using ELISA. The results showed that all treatment groups had significantly lower MDA levels and higher SOD activity compared to the controls (p < 0.05). The best results were found in the group that received 400 mg/kg. There was also a strong negative correlation between MDA and SOD levels (r = –0.855; p = 0.000). These findings suggest that turmeric extract may be useful as a natural antioxidant to reduce oxidative stress caused by too much physical activity.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Fransiska Fransiska
AU  - Ali Napiah Nasution
AU  - Qori Fadillah
PY  - 2026
DA  - 2026/01/02
TI  - The Effect of Turmeric (Curcuma longa) Extract Administration on Malondialdehyde (MDA) Levels and Superoxide Dismutase (SOD) Activity in Wistar Rats (Rattus norvegicus) Induced by Excessive Physical Activity
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 87
EP  - 93
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_10
DO  - 10.2991/978-94-6463-962-9_10
ID  - Fransiska2026
ER  -