Effectiveness Test of Nanoemulsion Preparation of Lemongrass Extract (Cymbopogon citratus L.) Through Histopathological Observation of the Pancreas of Diabetes Mellitus Rats by Observing the β $$\beta $$ Cell Profile of the Islets of Langerhans in Pancreatic Tissu

DOI

10.2991/978-94-6463-962-9_11How to use a DOI?

Keywords

Lemongrass; Nanoemulsion; Kidney; Urea; Creatinine; Diabetes

Abstract

When blood sugar levels drop to a certain point, cells break down glycogen into glucose to produce energy. If the pancreas does not produce enough insulin, or if the body’s cells do not respond well to the insulin it produces, diabetes can develop. This research was conducted to see how the effectiveness test of nanoemulsion preparation of lemongrass extract (Cymbopogon citratus L.) through histopathological observation of the pancreas of diabetic rats. With a sample of 20 Wistar rats divided into five groups, namely positive and negative control groups, and treatment groups 1, 2, and 3. The results show that the extract contains active compounds such as citral, geraniol, myrcene, and flavonoids, which have antihyperglycemic, antioxidant, anti-inflammatory, and hepatoprotective effects. It was effective in reducing blood glucose levels in rats with diabetes mellitus and improving the morphological structure of the rat pancreas, as seen from the histopathological images of the pancreatic tissue by observing the profile of β cells in the islets of Langerhans.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Angelina Herman Darmawan
AU  - Ermi Girsang
AU  - Sri Wahyuni Nasution
PY  - 2026
DA  - 2026/01/02
TI  - Effectiveness Test of Nanoemulsion Preparation of Lemongrass Extract (Cymbopogon citratus L.) Through Histopathological Observation of the Pancreas of Diabetes Mellitus Rats by Observing the 
                β
              $$\beta $$ Cell Profile of the Islets of Langerhans in Pancreatic Tissu
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 94
EP  - 105
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_11
DO  - 10.2991/978-94-6463-962-9_11
ID  - Darmawan2026
ER  -