Activity Test of Bay Leaf Extract Nanoemulsion Preparation (Syzygium Polyanthum) on Glucose and Malondialdehyde (MDA) Levels and Histopathological Features of the Liver in Male Rats (Rattus Norvegicus) Induced by Streptozotocin

DOI

10.2991/978-94-6463-962-9_13How to use a DOI?

Keywords

Leaf Greetings; MDA; Glucose levels; Liver

Abstract

This study aims to test the activity of bay leaf (Syzygium polyanthum) extract nanoemulsion preparations on glucose and malondialdehyde (MDA) levels as well as liver histopathology in male rats (Rattus norvegicus) induced by streptozotocin. The method used includes the preparation of nanoemulsion preparations and measurement of glucose and MDA levels as indicators of oxidative stress. Rats were divided into control and treatment groups, where the treatment group received bay leaf extract nanoemulsion preparations. The results showed that treatment with nanoemulsion significantly reduced glucose and MDA levels compared to the control group. Nanoemulsion extract Bay leaves (Syzygium Polyanthum) contain secondary metabolites in the form of saponins, tannins, flavonoids, and triterpenoids which help repair liver cells that experience fatty liver and necrosis due to diabetes mellitus. Histopathological images of the liver show tissue repair, indicating the potential of bay leaf extract in protecting the liver from damage due to diabetes. The results of histopathological observations of liver tissue in treatment group 3 are nanoemulsion extract Bay leaves ( Syzygium Polyanthum) with a concentration of 3.5% experienced the most significant improvement and approached the control group compared to the other groups. This study concludes that bay leaf extract nanoemulsion preparation can function as an effective therapy in managing diabetes complications. And lower MDA levels.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Gelen Sofiyanti
AU  - Chrismis Novalinda Ginting
AU  - Linda Chiuman
PY  - 2026
DA  - 2026/01/02
TI  - Activity Test of Bay Leaf Extract Nanoemulsion Preparation (Syzygium Polyanthum) on Glucose and Malondialdehyde (MDA) Levels and Histopathological Features of the Liver in Male Rats (Rattus Norvegicus) Induced by Streptozotocin
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 117
EP  - 128
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_13
DO  - 10.2991/978-94-6463-962-9_13
ID  - Sofiyanti2026
ER  -