Flavonoid Content and Antioxidant Activity of Various Parts of Sappan Wood (Caesalpinia sappan L.): Promising Candidates for Pharmaceutical and Medical Application

DOI

10.2991/978-94-6463-760-1_27How to use a DOI?

Keywords

ethyl acetate; flavonoid; IC50; parts of sappan wood

Abstract

Flavonoids, an essential class of phytochemicals in sappan wood, have significant pharmaceutical and medical applications. Despite the broad utility of the plant, current use is primarily focused on the bark, leaving other parts underexplored phytochemically. Understanding the bioactivity of various plant parts is critical, as bioactivity can differ significantly based on the plant component. This study aimed to analyze the bioactivity differences among several parts of the sappan wood plant—bark, seeds, and leaves—using ethyl acetate as a solvent. This analytical study utilized three samples per observation, with variables including flavonoid levels, percentage inhibition, and IC50 values. The results showed flavonoid levels of 0.170 mg/100 g in bark, 0.032 mg/100 g in seeds, and 0.147 mg/100 g in leaves. Percentage inhibition was 67.712% in bark, 37.43% in seeds, 49.815% in leaves, and 48.054% in vitamin C. IC50 values were 19.7 for bark, 87.95 for seeds, 52.37 for leaves, and 54.06 for vitamin C. The findings indicate that sappan wood bark exhibits superior levels of flavonoids, percentage inhibition, and IC50 values compared to other plant parts, making it the most potent source of natural antioxidants when extracted with ethyl acetate. These results highlight the bark as the most promising component of sappan wood for further development in antioxidant-based applications.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Ulfa Nurullita
AU  - Zoki Abadi Harahap
PY  - 2025
DA  - 2025/07/03
TI  - Flavonoid Content and Antioxidant Activity of Various Parts of Sappan Wood (Caesalpinia sappan L.): Promising Candidates for Pharmaceutical and Medical Application
BT  - Proceedings of the 3rd Lawang Sewu International Symposium on Medical and Health Sciences (LEWIS-MHS 2024)
PB  - Atlantis Press
SP  - 304
EP  - 319
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-760-1_27
DO  - 10.2991/978-94-6463-760-1_27
ID  - Nurullita2025
ER  -