Proceedings of the Workshop on Computation: Theory and Practice (WCTP 2025)

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Developing Immersive Gamification Technology Systems for the Management of Patients with Alzheimer’s Disease with Behavioral and Psychological Symptoms of Dementia: A Phase 2 Clinical Trial Protocol

Authors
Veeda Michelle M. Anlacan1, 3, *, Roland Dominic G. Jamora1, 3, Isabel Teresa O. Salido1, Bryan Andrei C. Galecio1, 6, Angelo Cedric F. Panganiban1, Maria Eliza R. Aguila1, 2, Ben Anthony A. Lopez1, 3, Christian Alfredo K. Cruz1, Louie Lorenzo M. Alcantara1, Cherica A. Tee1, 4, Jaime D. L. Caro1, 5, Michael L. Tee1, 7
1Augmented Experience eHealth Laboratory, University of the Philippines Manila, Manila, Philippines
2Department of Physical Therapy, College of Allied Medical Professions, University of the Philippines Manila, Manila, Philippines
3Department of Neurosciences, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
4Department of Pediatrics, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
5Department of Computer Science, College of Engineering, University of the Philippines Diliman, Quezon City, Philippines
6Department of Game Design and Development, School of Management and Information Technology - Analytics, Computing and Infotech Cluster, De La Salle - College of St. Benilde, Manila, Philippines
7Department of Physiology, College of Medicine, University of the Philippines Manila, Manila, Philippines
*Corresponding author. Email: axel@up.edu.ph
Corresponding Author
Veeda Michelle M. Anlacan
Available Online 30 April 2026.
DOI
10.2991/978-94-6239-638-8_11How to use a DOI?
Keywords
Immersive gamification; Alzheimer’s disease; clinical trial; dementia; virtual reality; augmented reality
Abstract

Alzheimer’s disease cases in the Philippines are expected to increase exponentially by 2040. Non-pharmacological management of this disease involves physical therapy, occupational therapy, speech therapy, art therapy, and music therapy, which can be simulated in a virtual environment through an immersive gamification technology system (ImGTS). This study describes a protocol designed for a Phase 2 clinical trial using ImGTS for persons living with dementia (PLWD). The study will use a randomized two-arm parallel clinical trial design, which will involve thirty PLWD who will undergo four sessions of therapy using the ImGTS. Clinical effectiveness, safety, and usability will be measured before and after each session. Secondary data will also be collected to measure cognitive function and quality of life. The paired t-test will be used to determine if there are significant differences between pretest and posttest scores, while Cohen’s d will illustrate the size of the effect observed. Ethical clearance was sought from the University of the Philippines Manila Research Ethics Board (UPMREB). This clinical trial was registered at clinicaltrials.gov (trial registration number: NCT06072014).

Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Workshop on Computation: Theory and Practice (WCTP 2025)
Series
Atlantis Highlights in Computer Sciences
Publication Date
30 April 2026
ISBN
978-94-6239-638-8
ISSN
2589-4900
DOI
10.2991/978-94-6239-638-8_11How to use a DOI?
Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Veeda Michelle M. Anlacan
AU  - Roland Dominic G. Jamora
AU  - Isabel Teresa O. Salido
AU  - Bryan Andrei C. Galecio
AU  - Angelo Cedric F. Panganiban
AU  - Maria Eliza R. Aguila
AU  - Ben Anthony A. Lopez
AU  - Christian Alfredo K. Cruz
AU  - Louie Lorenzo M. Alcantara
AU  - Cherica A. Tee
AU  - Jaime D. L. Caro
AU  - Michael L. Tee
PY  - 2026
DA  - 2026/04/30
TI  - Developing Immersive Gamification Technology Systems for the Management of Patients with Alzheimer’s Disease with Behavioral and Psychological Symptoms of Dementia: A Phase 2 Clinical Trial Protocol
BT  - Proceedings of the  Workshop on Computation: Theory and Practice (WCTP 2025)
PB  - Atlantis Press
SP  - 152
EP  - 240
SN  - 2589-4900
UR  - https://doi.org/10.2991/978-94-6239-638-8_11
DO  - 10.2991/978-94-6239-638-8_11
ID  - Anlacan2026
ER  -