A Network Biology Investigation of Amorphophallus Muelleri as a Promoter of Gut Health in Broiler Chicken

DOI

10.2991/978-94-6463-880-6_38How to use a DOI?

Keywords

A. muelleri; LpxC inhibition; Antibacterial agents; Molecular docking; Glucomannan

Abstract

Gut health is influenced by microbiota balance, directly affecting the poultry’s nutrient absorption efficiency and overall production performance. Despite the microbial modulation activity of Amorphophallus muelleri has been evaluated, the molecular mechanism remains poorly understood. This study investigated the antibacterial potential of bioactive compounds in A. muelleri flour, focusing on their interaction with LpxC, a key enzyme in bacterial lipid biosynthesis. Using molecular docking and dynamics simulations, five compounds—glucomannan, mannan, quercetin, orientin, and hyperoside—were assessed for their binding affinity to LpxC’s active site, with the native ligand’s binding affinity as a reference. Glucomannan, mannan, and quercetin demonstrated the strongest affinities and optimal binding profiles, with glucomannan showing the highest stability through extensive interactions. Molecular dynamics confirmed glucomannan’s robust stability, supported by RMSF data, and highlighted its potential as an effective LpxC inhibitor. Mannan and quercetin also displayed significant binding stability, indicating promise as antibacterial agents. The findings suggest that glucomannan’s stability, hydrogen bonding capacity, and bioactivity make it particularly effective, while mannan and quercetin offer additional potential. Overall, these results support the feasibility of A. muelleri flour as a natural antibacterial resource, providing a foundation for the development of safer, plant-derived antibiotics targeting LpxC to address bacterial infections and resistance.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Harits Ghozi Muzaki Sartono
AU  - Osfar Sjofjan
AU  - Yuli Frita Nuningtyas
AU  - Feri Eko Hermanto
AU  - Yoga Dwi Jatmiko
AU  - Muhammad Halim Natsir
PY  - 2025
DA  - 2025/10/31
TI  - A Network Biology Investigation of Amorphophallus Muelleri as a Promoter of Gut Health in Broiler Chicken
BT  - Proceedings of the 11th International Conference of Innovation in Animal Science (ICIAS 2024)
PB  - Atlantis Press
SP  - 341
EP  - 353
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-880-6_38
DO  - 10.2991/978-94-6463-880-6_38
ID  - Sartono2025
ER  -