All of the articles in this proceedings volume have been presented at SDDND-2025 during 22-23rd January 2025 in Nirmala College of Pharmacy, Atmakur, Mangalgiri, Guntur, Andhra Pradesh. These articles have been peer reviewed by the members of the Scientific Committee, and approved by the Editor-in-Chief,...

Losartan, an angiotensin receptor blocker utilized in treating hypertension, exhibits a biological half-life of around 1.5 to 2 h, necessitating frequent administration. To reduce the frequency of dose, attain targeting effect, and improve patient compliance. To achieve a sustained release profile, Losartan...

A simple, accurate, and precise method was developed to estimate Simnotrelvir and Ritonavir in pharmaceutical dosage form. Chromatography is used on a phenyl column (‘2.1 mm x 100 mm, 1.7 µm’) using a ‘mobile phase’ consisting of ‘0.1% formic acid’ and acetonitrile in ‘60:40 v/v’ ‘ratio’, with a ‘flow...

The journey to develop drugs is long, time-consuming, and costly. Most drugs take years and billions of dollars before they hit the market. Traditional computations remain useful but have inadequacies to accurately reproduce molecular interactions and predict drug efficacy. Quantum computing represents...

Rheumatoid arthritis is the most disabling autoimmune condition with persistent inflammation and severe joint destruction. Research conducted in the last decade points to the JAK/STAT signaling pathway as a new contender in the management of RA. The new DMARDs that have been recently approved by the...

Traditionally applied medicinal plants are of great importance, and the trend of using these medicinal plants is increasingly important in the world due to their fewer side effects. Madhumeha Nivarana Churnam is an indigenous ayurvedic formulation is focused on this research study to establish the claimed...

Transmucosal nasal drug delivery has become a major player in the field of drug delivery technology during the past few decades as a non-invasive method. “Rasagiline mesylate (RM) is a MAO-B inhibitor used in the treatment of idiopathic Parkinson's disease”, currently available in oral solid dose...

The objective of the study was to elevate the solubility, dissolution, and oral bioavailability of a practically insoluble hyperlipidemia drug Atorvastatin calcium. 23 factorial design and solvent antisolvent precipitation were used to create atorvastatin calcium nanocrystals (NCs). Particle size, drug...

The Synthesis of nanoparticles has attracted significant interest based on their possible applications in catalysis, medicine, and environmental detoxification. Toxic chemicals and energy consumption are used by most traditional techniques, which have severe environmental consequences. Microbial-mediated...

Artificial intelligence (AI), notably artificial neural networks (ANNs), is right now propelling an evolution in pharmaceutical research and development (R&D). This study explores the classification, applications, and uses of AI and ANNs in the pharmaceutical business, focusing on their significance...

The need for biodegradable nanoparticles as part of environmentally friendly drug delivery has grown tremendously over the years. These nanoparticles have several advantages biocompatibility, low toxicity, and rather minimal negative effects on the environment due to their lipid, protein, and polysaccharide...

Nanosponges are new colloidal drug carriers with nanosized cavities to encapsulate both lipophilic and hydrophilic drug moieties. They can circumvent the various formulation challenges associated with poor water solubility, low bioavailability, targeting, and controlled release of actives. Lovastatin,...

Chronic kidney disease (CKD) is defined as kidney damage or a glomerular filtration rate (GFR) of less than 60 ml/min/1.73 m2 for three months or longer. An artificial method for eliminating waste and extra water from the body is dialysis., is the only option for preserving renal function and patient...

Endothelial dysfunction is described by unbalanced dilation and constriction of blood vessel, elevated reactive oxygen species, and others factors, as well as low level of NO bioavailability. The presence of endothelial dysfunction breaks the barrier permeability that is a portion of inflammatory response...

Cellular senescence, characterized by the indefinite division of cells, is a key contributor to age-related diseases. Senescent cells release bioactive molecules, including exosomes that communicate with each other. These small extracellular vesicles have a dual role, either promoting or inhibiting certain...

Proton Pump Inhibitors (PPIs) are commonly prescribed for the treatment of acid-related disorders; however, prolonged use of these medications is associated with various adverse drug reactions (ADRs) that can have significant implications for patient health. This prospective observational study was conducted...

Globally about 10 million deaths was reported due to cancer in the year of 2022. In the year 2020 the new cases reported are as follows 2.26 million breast cancer cases; 2.21 million lung cancer cases; 1.93 million colon and rectum cancer cases; 1.41 million prostate cancer cases; 1.20 million skin (non-melanoma)...

Polypharmacy refers to consumption of many drugs to treat various illnesses, is common amongst elderly people suffering multiple medical conditions. Although this can seem as being the natural way of action, it brings with it a unique array of challenges. Taking several drugs might have negative consequences...

Epilepsy exists as a common neuropsycological condition marked with frequent spontaneous convulsive attacks. Sometimes accompanied by unconsciousness. It is anticipated to have an impact on 50 million of individuals globally. The present investigation aims towards the evaluation of Quality of life in...

A persistent, mild psychological and physical ailment that appears during the luteal phase of feminine periods and goes away with menstruation is called premenstrual syndrome. Headaches, numbness, increased limb sensitivity, palpitations, lightheadedness, and gastrointestinal and ophthalmic symptoms...

The dorsolumbar region is the primarily affected deformity in Pott’s spine, gradually progressing to vertebral destruction, spinal canal narrowing, and neurological impairments. Considering, it as an extrapulmonary infection Mycobacterium tuberculosis has a very uncommon and low incidence of < 1%...

Our study aimed to understand the impact of urinary tract infections (UTIs) on newborn outcomes. Aimed to assess if maternal UTIs increases neonatal co-morbidities like preterm labor, neonatal low birth weight, neonatal sepsis& NICU hospitalisation. Out of 150 pregnant patients from Andhrapradesh,...

Although advanced technology and computerized systems have improved the field of medicine, we still see medication errors. Globally, respiratory disorders and their associated drug related problems have a significant impact, A study found that medication non adherence in asthma patients resulted in additional...

Diabetic wounds, a severe consequence among diabetic patients, significantly contribute to disability and mortality. A significant part of this work on the pathophysiology of diabetic wound healing has mostly focused on processes driven by chronic inflammation, hyperglycaemia and dysfunctions in microcirculation....

In clinical background, an anti-tuberculosis medication that may harm the liver. The medicinal plant Brassica nigra L (Brassicaceae) has anticancer and antioxidant properties. Brassica nigra L. hydroalcoholic extracts were screened for antitubercular activity using the NRA and BacT/Alert methods. It...

Tuberculosis ranks as the second deadliest infection caused by a single causative agent worldwide. Resistance towards the existing anti tubercular agents is the result of under diagnosis, phenotypic and genetic variation among patients and non-adherence to the current therapy. Drug discovery towards...

Prescription errors are one of the leading cause of harm to the patient at the time of discharge, although advanced technology and computerized systems have improved the field of medicine, medication errors will occur. According to who unsafe medication practices and prescription errors are a leading...

Chronic pain is a common problem affecting the most of the population. This implicates the use of both conventional and alternative therapies. The main objective of the study is to identify efficacies of conventional as well as combinational therapy among individuals with chronic pain. Total of 150 individualshad...

Micro RNAs, commonly known as miRNAs, are short-stranded non-coding RNA sequences that are of extreme importance in the regulation of gene expression since they are involved in the stability and the translational efficiency of them RNAs. MiRNAs were almost exclusively studied in relation to their target...

Chandipura virus (CHPV) is a highly virulent and neurotropic pathogen that has caused significant outbreaks in India, resulting in high mortality rates, particularly among children. The virus is primarily transmitted through the bite of infected sand flies, and its rapid progression and high mortality...

Mangroves are important – for the life on the earth. Coastal regions that are tropical or subtropical are home to mangrove forests, supporting a vast variety of animals, both above and below the water, that provide food and shelter. Mangrove plants are associated with the microorganisms of endophytes...

A significant public health issue, urinary tract infections (UTIs) is more common in women (59%) than in men. E. coli is the most commonly isolated pathogen (52%), with K. pneumoniae and Staphylococcus following closely behind. According to our research, Gram-positive bacteria are resistant to trimethoprim,...

Nirmatrelvir is an antiviral medication used in the treatment of COVID-19. It functions by inhibiting a specific protease, a protein essential for viral replication. Blocking this protease disrupts the virus's ability to multiply and continue its infectious cycle. Due to the clinical importance...