All of the articles in this proceedings volume have been presented at the 1st International Conference on Lifestyle Disease and Natural Medicine (1st ICOLIFEMED), held on December 5, 2024, at Universitas Prima Indonesia, Medan, Indonesia. These articles have been peer-reviewed by the members of the International...

Sepsis caused by Staphylococcus aureus disrupts hematologic, metabolic, and immune functions. Zinc and vitamin E, with antioxidant and immunomodulatory properties, may mitigate these effects. Thirty male Wistar rats aged 12 to 16 weeks and weighing 150 to 200 grams were randomized into six groups of...

Lifestyle-related diseases are rising in Indonesia, underscoring the importance of identifying lifestyle factors that individuals can modify through their own efforts. This study aimed to clarify lifestyle determinants of hypertension and metabolic syndrome using health checkup data and lifestyle surveys....

Lifestyle medicine emphasizes preventive behaviours such as diet, exercise, and adequate sleep, yet immunization also represents a vital practice for sustaining individual and community health. This study evaluated the protective role of measles vaccination against confirmed measles cases in Kelantan,...

Courier workers face high occupational demands that may impact their health, including gastrointestinal disorders. This study aimed to analyze the association between workload, work fatigue, and the incidence of gastric acid disease among package delivery couriers. An observational analytical study with...

Hypertension, commonly known as high blood pressure, is a condition characterized by a persistent increase in pressure within the arterial system. Professional drivers face a higher risk of developing hypertension due to factors such as genetics, lack of physical activity, obesity, excessive salt intake,...

Ascaris lumbricoides infection is a major public health problem in Indonesia, especially in children. This infection can interfere with nutrient absorption and contribute to malnutrition. This study aims to determine the relationship between Ascaris lumbricoides infection and the nutritional status of...

Previous studies have shown that antioxidants in beetroot (Beta vulgaris) extract may aid in nephron protection and exhibit anti-hypercholesterolemic effects by reducing reactive oxygen species (ROS). This study aimed to evaluate the effectiveness of beetroot extract as a nephroprotective and anti-hypercholesterolemic...

The increasing prevalence of type 2 diabetes mellitus (T2DM) highlights the need for safer, more accessible treatment alternatives beyond current pharmacotherapies, which often cause adverse effects. Plant-based interventions rooted in ethnopharmacological traditions have gained traction. Solanum mauritianum...

Excessive physical activity can increase the production of free radicals, which may cause oxidative stress if the body’s antioxidant system cannot handle it. This study aimed to find out whether turmeric extract can help reduce malondialdehyde (MDA) levels and increase superoxide dismutase (SOD) activity...

When blood sugar levels drop to a certain point, cells break down glycogen into glucose to produce energy. If the pancreas does not produce enough insulin, or if the body’s cells do not respond well to the insulin it produces, diabetes can develop. This research was conducted to see how the effectiveness...

The kidneys are a vital part of the body that maintains a stable body condition. High blood glucose levels are a sign of a chronic disease known as diabetes mellitus. In this study,see howActivity test of nanoemulsion preparation of lemongrass extract (Cymbopogon Citratus L.) on reducing urea, creatinine,...

This study aims to test the activity of bay leaf (Syzygium polyanthum) extract nanoemulsion preparations on glucose and malondialdehyde (MDA) levels as well as liver histopathology in male rats (Rattus norvegicus) induced by streptozotocin. The method used includes the preparation of nanoemulsion preparations...

The liver is a vital organ in the body that plays a role in the metabolism of toxic substances. Type 2 diabetes mellitus increases the risk of microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular (cardiovascular) complications. This study aims to examineeffectiveness of lemongrass...

Maintaining blood sugar balance is essential for proper kidney, liver, and brain function. Diabetes can be caused by damage to pancreatic cells from chronic pancreatitis. One plant with potential benefits for diabetes sufferers is lemongrass (Cymbopogon nardus L.). The research sample consisted of 24...

This study aims to evaluate the influence of turmeric rhizome extract nanoemulsion Curcuma domestica Val on the reduction of C Reactive Protein CRP and Myeloperoxidase MPO levels in Wistar rats with diabetes mellitus. The results of the study showed that GC MS analysis of turmeric compounds included...

This study aims to evaluate the effectiveness of mint leaf extract nanoemulsion (Mentha piperita L) on serum urea levels and glomerular filtration rate (GFR) in alloxan-induced hyperglycemic Wistar rats. The active substance content in mint leaf extract (Mentha piperita L) through Gc Ms Analysis, namely...

Maintaining the natural moisture balance of the skin is referred to as skin hydration. This is achieved by supplying the skin with adequate moisture. Prolonged exposure to ultraviolet B radiation causes the skin to produce reactive oxygen species. Excessive reactive oxygen species triggers the activation...

Etlingera elatior a tropical plant commonly found in Indonesia, is traditionally used for its medicinal properties. However, limited studies have explored its bioactive content and antibacterial effects. This study aimed to identify the phytochemical constituents and evaluate the antibacterial activity...

Hyperpigmentation can be treated using topical, systemic, or procedural approaches. Eudrilus eugeniae earthworms, abundant in Indonesia, have potential skin benefits, including blemish reduction and skin tightening. This study evaluated the effect of E. eugeniae coelomic fluid on hyperpigmentation in...

Castanopsis costata, a species from the Fagaceae family, has been traditionally used for medicinal purposes, yet its antibacterial potential remains largely unexplored. This study aimed to evaluate the phytochemical constituents and antibacterial activity of C. costata leaf extract against Staphylococcus...

Sunkist orange peel (Citrus sinensis (L.) Osbeck) is known to contain various bioactive compounds such as flavonoids, vitamin C, vitamin A, tannins, saponins, and antioxidants, which have potential to support wound healing through anti-inflammatory, antioxidant, and tissue regeneration mechanisms. This...

Sepsis induced by Staphylococcus aureus triggers widespread inflammation, oxidative stress, and metabolic disturbance, leading to hematologic impairment, altered glycemic control, and immune dysregulation. This study evaluates the effects of Centella asiatica extract combined with ascorbic acid on hemoglobin,...

The increasing resistance of pathogenic bacteria such as Sta-phylococcus aureus to conventional antibiotics highlights the need for alternative antimicrobial agents derived from natural sources. This study aimed to analyze the phytochemical constituents and evaluate the antibacterial activity of Mitragyna...

Burn injuries are severe tissue traumas that induce complex inflammatory responses and require effective treatments to support the healing process. Vascular Endothelial Growth Factor (VEGF) and collagen play crucial roles in angiogenesis and tissue remodeling during wound healing. Moringa oleifera L....

Background: Vitamin D and its receptor (VDR) play a pivotal role in immune regulation, with polymorphisms in the VDR gene implicated in susceptibility to systemic autoimmune rheumatic diseases (SARDs). Objective: This review compares findings from Asian and European populations regarding VDR polymorphisms...

Benzoapyrene is a polycyclic aromatic hydrocarbon that can cause liver injury through oxidative stress and has carcinogenic potential. Zanthoxylum acanthopodium, known as andaliman, is a traditional spice from North Sumatra containing bioactive compounds with antioxidant and hepatoprotective activity....

Chronic wounds remain a major clinical and economic challenge worldwide. Natural-product–based topical therapies are attractive alternatives due to biocompatibility, multi-target activity and cost-effectiveness. Paraboea leuserensis, an Indonesian endemic medicinal plant, has recently attracted attention...

Polysistic Ovary Syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age, characterized by hyperandrogenism, ovulatory dysfunction, and the presence of polycystic ovaries. Existing treatment options frequently result in adverse effects, emphasizing the necessity for safer, plant-derived...

Diabetes mellitus is a chronic metabolic condition characterized by high blood sugar levels caused by reduced insulin production, reduced response to insulin, or both [1]. Many traditional plants can lower blood sugar levels, but their use is often based solely on experience without sufficient clinical...

This study explores the antioxidant potential of Leea aequata L. leaves through in vitro evaluation to identify and characterize bioactive compounds responsible for its antioxidant activity. The leaves were extracted, fractionated, and purified, and the antioxidant capacity was assessed using the DPPH...

Leea aequata (L.), or Titanus leaf, is a tropical plant containing phenolic and flavonoid compounds with high antioxidant and antibacterial activity, but its low solubility and thermal instability limit its biological effectiveness. This research aims to develop and evaluate nanoemulsions of ethanol...

Currently, degenarative disease are a major in Indonesia, affecting approximately thirty percent of the population. As an alternative treatment, Indonesia communities tend to Prefer herbal or traditional medicines. One widely used plant is Titanus leaf (Leea aequata L.) using the wet granulation method....

The increasing elderly population and high prevalence of non-communicable diseases in Indragiri Hulu Regency have positioned preventive healthcare services as a primary priority. However, the utilization of these services among the elderly is influenced by multiple factors. This study aimed to analyze...

Depression represents a serious mental health disorder among elderly individuals that is frequently underrecognized, with significant prevalence rates documented in Indonesia. In Medan City, demographic transitions and urbanization challenges potentially increase the risk of depression within the elderly...

Breast cancer survival varies across populations, and in Malaysia’s multi-ethnic setting, differences between groups have been consistently observed. This retrospective cohort study examined ethnic variations in survival among Malaysian women with breast cancer diagnosed between 2015–2019, using data...

Type 2 diabetes mellitus is an important lifestyle related disease which carries the risk of diabetic retinopathy. Diabetic retinopathy can lead to blindness, a serious disability that will significantly affect patients quality of life. This study aimed to determine the event probability and prevalence...

This study explores the use of Extended Reality (XR) technology in medical professional education, focusing on infection control and medical device operation training. Infection prevention requires strict recognition of sterile and non-sterile areas, yet traditional methods such as lectures and limited...